Title |
Description |
Inventors |
Country |
Number |
GENETIC CONSTRUCTS FOR DELAYING OR REPRESSING THE EXPRESSION OF A TARGET GENE (‘099) |
Synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the invention provides novel synthetic genes and genetic constructs which are capable of repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto. |
Graham, Rice, |
US |
6,573,099 |
SYNTHETIC GENES AND GENETIC CONSTRUCTS COMPRISING THE SAME (Graham Family)
|
A method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilises recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in a cell, tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable or repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto are also provided. |
Waterhouse, Graham, Wang, Rice |
US |
7,754,697
|
US |
7,855,071 |
|||
CONTROL OF GENE EXPRESSION WO99/49029
|
A method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the invention utilises recombinant DNA technology post-transcriptionally modify or modulate the expression of a target gene in a cell, tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable or repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto are also provided. |
Graham, Rice, Waterhouse, Wang |
AUS |
743316 |
AUS |
2005202658 |
|||
AUS |
2005211538 |
|||
AUS |
2005209648 |
|||
AUS |
2008249157 |
|||
CANADA |
2323726 |
|||
CZECH REP |
295108 |
|||
UK |
GB 2353282 |
|||
HK |
1035742 |
|||
INDIA |
3413/DELNP/2005 & 3901/DELNP/2005 |
|||
INDIA |
2000/00169/DE |
|||
JAPAN |
2000-537990 |
|||
JAPAN |
2005-223953 |
|||
JAPAN |
2007-302237 |
|||
NZ |
506648 |
|||
NZ |
547283 |
|||
SINGAPORE |
75542 |
|||
SINGAPORE |
200205122.5 |
|||
SINGAPORE |
141233 |
|||
SLOVENIA |
287538 |
|||
S. AFRICA |
2000/4507 |
Patent Name |
Description |
Inventors |
Country |
Application/ Grant No |
METHODS AND MEANS FOR OBTAINING MODIFIED PHENOTYPES |
Methods for reducing the phenotypic expression of a nucleic acid of interest in eukaryote cells by providing aberrant RNA molecules, preferably unpolyadenylated RNA molecules comprising at least one target specific nucleotide sequence homologous to the nucleic acid of interest, preferably a sense strand, into the nucleus of the cells. |
Waterhouse Wang Graham
|
AU |
29514/99 (760041) |
Title and Benitec Ref No. |
Description |
Inventors |
EX |
Number |
MULTIPLE PROMOTER EXPRESSION CASSETTES FOR SIMULTANEOUS DELIVERY OF RNAi AGENTS |
A genetic construct comprising a multi-promoter expression cassette comprising at least three promoter/RNAi/terminator components wherein each promoter/RNAi/terminator component comprises a promoter element, a terminator element and an RNAi species operably linked to the promoter element and the terminator element, and wherein each of the RNAi species is different from one another.
|
Roelvink, Suhy, Kolykhalov |
NZ |
550284 |
AUS |
200522084 |
|||
EU |
05727680.0 |
|||
USA |
7727970 |
|||
GENETIC SILENCING |
A method of inducing, promoting or otherwise facilitating a change in the phenotype of an animal cell or group of animal cells including an animal. The modulation of phenotypic expression is accomplished via genotypic manipulation by inducing, promoting or otherwise facilitating the silencing of expressible genetic sequences thus reducing translation of transcript to protein. Expressible genetic sequences contemplated by the invention include not only genes normally resident in a particular cell (i.e. indigenous genes) but also genes introduced through recombinant means or through infection by pathogenic agents such as viruses. |
Graham, Rice, Murphy, Reed |
UK |
GB2377221 |
SINGAPORE |
91678 |
|||
S. AFRICA |
2002/07428 |
|||
DOUBLE-STRANDED NUCLEIC ACID
|
A ribonucleic acid (RNA) for use as interfering RNA in gene silencing techniques to silence a target gene comprising in a 5’ to 3’ direction at least four sequences being a first and second effector sequence 17 to 21 nucleotides in length; a sequence substantially complementary to the second effector sequence; and a sequence substantially complementary to the first effector sequence; wherein the complementary sequences are capable of forming double stranded regions with their respective effector sequences and wherein at least one of the four sequences is substantially identical to the predicted transcript of a region of the target gene; and the RNA further comprising a spacing sequence of one or more nucleotides, the spacing sequence being located between and spacing the first effector sequence and the second effector sequence, or between the sequence substantially complementary to the second effector sequence and the sequence substantially complementary to the first effector sequence. |
Graham, Rice, Roelvink, Suhy, Kolkykhalov, Harrison, Reed |
AUS |
2004243347 |
NZ |
543815 |
|||
S. AFRICA |
2005/09813 |
|||
SINGAPORE |
200507474-5 |
|||
RNAi EXPRESSION CONSTRUCTS (single promoter)
|
Compositions and methods suitable for expressing 1-x RNAi agents against a gene or genes in cells, tissues or organs of interest in vitro and in vivo so as to treat diseases or disorders.
|
Roelvink, Suhy, Kolykhalov, Couto |
USA |
7,803,611 |
