Read more about ddRNAi and RNAi

For easier navigation, scientific publications about ddRNAi and RNAi are listed in 3 groups:

ddRNAi

Induction of Alloimmune Tolerance in Heart Transplantation Through Gene Silencing of TLR Adaptors
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Zhang X, Beduhn M, Zheng X, Lian D, Chen D, Li R, Siu LKS, Marleau A, French PW, Ichim TE, Min W-P . Am J Transplantation 2012 Jul 23.
Construction of simple and efficient DNA vector-based short hairpin RNA expression systems for specific gene silencing in mammalian cells.
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Cheng TL, Chang WT
Methods Mol Biol. 2007;408:223-41.

Is RNA interference involved in intrinsic antiviral immunity in mammals?
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Cullen BR.
Nat Immunol 2006. June; 7(6):563-7.
Viral delivery of recombinant short hairpin RNAs.
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Davidson BL, Harper SQ.
Meth Enzymol 2005. 392:145-73
Duplexes of 21±nucleotide RNAs mediate RNA interference in cultured mammalian cells
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Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Nature 2001. May; 411:494-8.
RNA interference by short hairpin RNAs expressed in vertebrate cells
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Hannon GJ, Conklin DS
Meth Mol Biol. 2004; 257:255-66.

Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others?
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Jaronczyk K, Carmichael JB, Hobman TC.
Biochem J 2005. May;387(Pt 3):561-71.
RNAi-mediated pathways in the nucleus.
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Matzke MA, Birchler JA.
Nat Rev Genet 2005 Jan;6(1):24-35
Gene silencing of virus replication by RNA interference.
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Miyano-Kurosaki N, Takaku H.
Handb Exp Pharmacol 2006. 173:151-71.
Effective expression of small interfering RNA in human cells
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Paul CP, Good PD, Winer I, Engelke DR.
Nature Biotechnol 2002. May; 20:505-8.

Molecular mechanisms of RNAi: implications for development and disease.
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Rao M, Sockanathan S.
Birth Defects Res C Embryo Today. 2005 Mar;75(1):28-42
Simple, robust strategies for generating DNA-directed RNA Interference constructs
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Rice RR, Muirhead AN, Harrison BT, Kassianos AJ, Sedlak PL, Maugeri NJ, Goss PJ, Davey JR, James DE, Graham MW
Meth Enzymol 2005; 392:405-19.

RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences.
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Robert VJ, Vastenhouw NL, Plasterk RH.
Cold Spring Harb Symp Quant Biol. 2004;69:397-402
Expressing short hairpin RNAs in vivo
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Snove O & Rossi JJ.
Nature Methods 2006; Vol.3 No.9: 689-695
Paradigms for conditional expression of RNA interference molecules for use against viral targets.
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Strayer DS, Feitelson M, Sun B, Matskevich AA.
Meth Enzymol 2005;392:227-41
The silent treatment: RNAi as a defense against virus infection in mammals.
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van Rij RP, Andino R.
Trends Biotechnol 2006. Apr; 24(4):186-93.
Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA.
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Waterhouse PM, Graham MW, Wang M-B.
Proc Natl Acad Sci USA 1998.
Nov; 95:13959-64.

Disease Pipeline

Use of RNA interference to modulate liver adenoma development in a murine model transgenic for hepatitis B virus.
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Chen CC, Chang CM, Sun CP, Yu CP, Wu PY, Jeng KS, Hu CP, Chen PJ, Wu JC, Shih CH, Gershwin ME, Tao MH Gene Ther. 2012 Jan; 19(1):25-33.

Hepatitis B virus inhibition in mice by lentiviral vector mediated short hairpin RNA
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Deng L, Li G, Lisen Xi, Yin A, Gao Y, You W, Wang X, Sun B.
BMC Gastroenterology 2009, 9:73-84.

RNA-based gene therapy for HIV with lentiviral vector-modified CD34+ cells in patients undergoing transplantation for AIDS-related lymphoma
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DiGiusto DL Krishnan A, Li L, Li H, Li S, Rao A, Mi S, Yam P, Stinson S, Kalos M, Alvarnas J, Lacey SF, Yee J-K, Li M, Couture L, Hsu D, Forman SJ, Rossi JJ, Zaia JA.
Sci Trans Med 2010. June; 2 Issue 36 36ra43.
Lentiviral vector-mediated gene transfer and RNA silencing technology in neuronal dysfunctions.
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Dreyer JL
Mol Biotechnol. 2011 Feb; 47(2):169-87.

Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells.
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Gan PP, McCarroll JA, Byrne FL, Garner J, Kavallaris M.
PLoS One. 2011;6(6):e21717.

Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs.
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Gu W, Payne E, Sun S, Burgess M, McMillan NAJ.
Cancer Gene Therapy 2011. 18:219-27
Progress on Gene Therapy, Cell Therapy, and Pharmacological Strategies Toward the Treatment of Oculopharyngeal Muscular Dystrophy
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Harish, P, Malerba A, Dickson G, and Bachtarzi H
HUMAN GENE THERAPY 26:286–292 (May 2015)
RNAi as a new therapeutic strategy against HCV
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Khaliq S, Khaliq SA, Zahur M, Ijaz B, Jahan S, Ansar M, Riazuddin S, Hassan S.
Biotech Adv 2010. 28:27-34
In vitro characterization of the activity of PF-05095808 a novel biological agent for Hepatitis C Virus therapy
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Lavender H, Brady K, Burden F, Delpuech-Adams O, Denise H. Palmer A, Hannah Perkins H, Savic B, Scott S, Smith-Burchnell C,Troke P, Wright JF, Suhy D, Corbau R.
Antimicrob Agents Chemother. 2012 Mar; 56(3):1364-75.

ßIII-tubulin Is a multifunctional protein involved in drug sensitivity and tumorigenesis in non-small cell lung cancer
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McCarroll JA, Gan PP, Liu M, Kavallaris M.
Cancer Res 2010 May;70(12):OF1-9
Simple, Robust Strategies for Generating DNA-Directed RNA Interference Constructs Rice RR, Muirhead AN, Harrison BT, Kassianos AJ, Sedlak PL, Maugeri NJ, Goss PJ, Davey JR, James DE, Graham MW.
Meth Enzymol 2005. 392:405-19.
Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer
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Senzer N, Barve M, Kuhn J, Melnyk A, Beitsch P, Lazar M, Lifshitz S, Magee M, Oh J, Mill SW, Bedell C, Higgs C, Kumar P, Yu Y, Norvell F, Phalon C, Taquet N, Rao DD, Wang Z, Jay CM, Pappen BO, Wallraven G, Brunicardi FC, Shanahan DM, Maples PB, Nemunaitis J.
Mol Ther 2012 Mar; 20(3): 679–686.

Gene knockdown with lentiviral vector-mediated intrathecal RNA interference of protein kinase C gamma reverses chronic morphine tolerance in rats.
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Song Z, Zou W, Liu C, Guo Q.
J Gene Med. 2010 Nov; 12(11):873-80.

The silent treatment: RNAi as a defense against virus infection in mammals. van Rij RP, Andino R.
Trends Biotechnol 2006. Apr;24(4):186-93.
Intrathecal lentiviral-mediated RNA interference targeting PKCγ attenuates chronic constriction injury-induced neuropathic pain in rats.
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Zou W, Song Z, Guo Q, Liu C, Zhang Z,
Zhang Y.
Hum Gene Ther. 2011 Apr; 22(4):465-75.

RNAi

RNAi: the nuts and bolts of the RISC machine.
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Filipowicz W.
Cell 2005 Jul;122(1):17-20
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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Fire A, Xu SQ, Montgomery MK, Kostas SA, Driver SE, Mello CC.
Nature 1998. Feb; 391:806-11.
Dicing and slicing: the core machinery of the RNA interference pathway.
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Hammond SM.
FEBS Lett 2005 Oct;579(26):5822-9
Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation.
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Hutvagner G.
FEBS Lett 2005 Oct;579(26):5850-7
Cell 2005 Jul;122(1):17-20

siRNA vs. shRNA: Similarities and differences
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Rao DD, Vorhies JS,  Senzer N, Nemunaitis J.
Advanced Drug Delivery Reviews 2009; 61: 746–759
Expanding small RNA interference
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Tuschl T.
Nature Biotechnol 2002. May; 20:446-8.

Targeted mRNA degradation by double-stranded RNA in vitro
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Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA.
Genes Dev 1999. 13:3191-7.

βIII-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer
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McCarroll JA et al
Oncotarget. 2015 Feb 10;6(4):2235-49.

 

βIII-tubulin overexpression is linked to aggressive tumor features and shortened survival in clear cell renal cell carcinoma.
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Alexander Q et al

World J Urol 2014 Dec 21.
Epub 2014 Dec 21.

TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer
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 McCarroll JA et al

Cancer Res. 2015 Jan 15;75(2):415-25. doi: 10.1158/0008-5472.CAN-14-2740.

Epub 2014 Nov 20.

Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision
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Denise H et al

Molecular Therapy Nucleic Acids (2014) 3, e145; doi:10.1038/mtna.2013.73